Cartilage and chondrocyte response to extreme muscular loading and impact loading: Can in vivo pre-load decrease impact-induced cell death?
نویسندگان
چکیده
منابع مشابه
In vivo Investigation of Patellofemoral Cartilage Contact Mechanisms- Impact of Mechanical Loading and Patellofemoral Geometry
This open-access article is published and distributed under the Creative Commons Attribution NonCommercial No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits the noncommercial use, distribution, and reproduction of the article in any medium, provided the original author and source are credited. You may not alter, transform, or build upon this article witho...
متن کاملA Theoretical Study Of The Mechanical Response Of Articular Cartilage To Impact Loading
INTRODUCTION Experimentally, the stresses of articular cartilage have been found to depend on the loading rate [1,2]. Theoretically, the short-term transient behavior of cartilage in unconfined compression has been explored at strain rates of 0.01, 0.1 and 1%/s using a poroviscoelastic model [3]. In the present work, the transient stress-strain relationship, the dependence of stiffness on tissu...
متن کاملImpact loading of articular cartilage during transplantation of osteochondral autograft.
Surgical reconstruction of articular surfaces by transplantation of osteochondral autografts has shown considerable promise in the treatment of focal articular lesions. During mosaicplasty, each cylindrical osteochondral graft is centred over the recipient hole and delivered by impacting the articular surface. Impact loading of articular cartilage has been associated with structural damage, los...
متن کاملP188 reduces cell death and IGF-I reduces GAG release following single-impact loading of articular cartilage.
Prior joint injury predisposes an individual to developing post-traumatic osteoarthritis, for which there is presently no disease modifying treatment. In this condition, articular cartilage degenerates due to cell death and matrix breakdown, resulting in tissue with diminished biomechanical function. P188, a nonionic surfactant, and the growth factor IGF-I have been shown to decrease cell death...
متن کاملThe mechanical and material properties of elderly human articular cartilage subject to impact and slow loading.
The mechanical properties of articular cartilage vary enormously with loading rate, and how these properties derive from the composition and structure of the tissue is still unclear. This study investigates the mechanical properties of human articular cartilage at rapid rates of loading, compares these with measurements at slow rates of loading and explores how they relate to the gross composit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Biomechanics
سال: 2015
ISSN: 0268-0033
DOI: 10.1016/j.clinbiomech.2015.04.009